Selected publications from the past 5 years

1.
Raghuraman R, Navakkode S, Sajikumar S. Alteration of hippocampal CA2 plasticity and social memory in adult rats impacted by juvenile stress. Hippocampus. 2023 Jun;33(6):745-758. doi: 10.1002/hipo.23531. Epub 2023 Mar 25. PMID: 36965045.
2.
Crombie EM, Kim S, Adamson S, Dong H, Lu TC, Wu Y, Wu Y, Levy Y, Stimple N, Lam WMR, Hey HWD, Withers DJ, Hsu AL, Bay BH, Ochala J, Tsai SY. Activation of eIF4E-binding-protein-1 rescues mTORC1-induced sarcopenia by expanding lysosomal degradation capacity. J Cachexia Sarcopenia Muscle. 2023 Feb;14(1):198-213. doi: 10.1002/jcsm.13121. Epub 2022 Nov 17. PMID: 36398408; PMCID: PMC9891956.
3.
Ang SJ, Crombie EM, Dong H, Tan KT, Hernando A, Yu D, Adamson S, Kim S, Withers DJ, Huang H, Tsai SY. Muscle 4EBP1 activation modifies the structure and function of the neuromuscular junction in mice. Nat Commun. 2022 Dec 17;13(1):7792. doi: 10.1038/s41467-022-35547-0. PMID: 36526657; PMCID: PMC9758177.
4.
Zhai J, Navakkode S, Yeow SQZ, Krishna-K K, Liang MC, Koh JH, Wong RX, Yu WP, Sajikumar S, Huang H, Soong TW. Loss of CaV1.3 RNA editing enhances mouse hippocampal plasticity, learning, and memory. Proc Natl Acad Sci U S A. 2022 Aug 9;119(32):e2203883119. doi: 10.1073/pnas.2203883119. Epub 2022 Aug 1. PMID: 35914168; PMCID: PMC9371748.
5.
Selvaraji S, Efthymios M, Foo RSY, Fann DY, Lai MKP, Chen CLH, Lim KL, Arumugam TV. Time-restricted feeding modulates the DNA methylation landscape, attenuates hallmark neuropathology and cognitive impairment in a mouse model of vascular dementia. Theranostics. 2022 Mar 21;12(7):3007-3023. doi: 10.7150/thno.71815. PMID: 35547760; PMCID: PMC9065201.
6.
Cnops V, Iyer VR, Parathy N, Wong P, Dawe GS. Test, rinse, repeat: A review of carryover effects in rodent behavioral assays. Neurosci Biobehav Rev. 2022 Apr;135:104560. doi: 10.1016/j.neubiorev.2022.104560. Epub 2022 Feb 3. PMID: 35124156.
7.
Poh XY, Hong JM, Bai C, Miow QH, Thong PM, Wang Y, Rajarethinam R, Ding CSL, Ong CWM. Nos2-/- mice infected with M. tuberculosis develop neurobehavioral changes and immunopathology mimicking human central nervous system tuberculosis. J Neuroinflammation. 2022 Jan 24;19(1):21. doi: 10.1186/s12974-022-02387-0. Erratum in: J Neuroinflammation. 2022 Aug 1;19(1):197. PMID: 35073927; PMCID: PMC8787888.
8.
Navakkode S, Zhai J, Wong YP, Li G, Soong TW. Enhanced long-term potentiation and impaired learning in mice lacking alternative exon 33 of CaV1.2 calcium channel. Transl Psychiatry. 2022 Jan 10;12(1):1. doi: 10.1038/s41398-021-01683-2. PMID: 35013113; PMCID: PMC8748671.
9.
Wong LR, Wong P, Ho PC. Metabolic Profiling of Female Tg2576 Mouse Brains Provides Novel Evidence Supporting Intranasal Low-Dose Pioglitazone for Long-Term Treatment at an Early Stage of Alzheimer's Disease. Biomedicines. 2020 Dec 9;8(12):589. doi: 10.3390/biomedicines8120589. PMID: 33317213; PMCID: PMC7764407.
10.
Poh L, Fann DY, Wong P, Lim HM, Foo SL, Kang SW, Rajeev V, Selvaraji S, Iyer VR, Parathy N, Khan MB, Hess DC, Jo DG, Drummond GR, Sobey CG, Lai MKP, Chen CL, Lim LHK, Arumugam TV. AIM2 inflammasome mediates hallmark neuropathological alterations and cognitive impairment in a mouse model of vascular dementia. Mol Psychiatry. 2021 Aug;26(8):4544-4560. doi: 10.1038/s41380-020-00971-5. Epub 2020 Dec 9. PMID: 33299135
11.
Peng AYT, Agrawal I, Ho WY, Yen YC, Pinter AJ, Liu J, Phua QXC, Koh KB, Chang JC, Sanford E, Man JHK, Wong P, Gutmann DH, Tucker-Kellogg G, Ling SC. Loss of TDP-43 in astrocytes leads to motor deficits by triggering A1-like reactive phenotype and triglial dysfunction. Proc Natl Acad Sci U S A. 2020 Nov 17;117(46):29101-29112. doi: 10.1073/pnas.2007806117. Epub 2020 Oct 30. PMID: 33127758; PMCID: PMC7682406.
12.
Wong LW, Chong YS, Wong WLE, Sajikumar S. Inhibition of Histone Deacetylase Reinstates Hippocampus-Dependent Long-Term Synaptic Plasticity and Associative Memory in Sleep-Deprived Mice. Cereb Cortex. 2020 Jun 1;30(7):4169-4182. doi: 10.1093/cercor/bhaa041. PMID: 32188968.
13.
Krishna-K K, Baby N, Raghuraman R, Navakkode S, Behnisch T, Sajikumar S. Regulation of aberrant proteasome activity re-establishes plasticity and long-term memory in an animal model of Alzheimer's disease. FASEB J. 2020 Jul;34(7):9466-9479. doi: 10.1096/fj.201902844RR. Epub 2020 May 27. PMID: 32459037.
14.
Wang W, Xiang P, Chew WS, Torta F, Bandla A, Lopez V, Seow WL, Lam BWS, Chang JK, Wong P, Chayaburakul K, Ong WY, Wenk MR, Sundar R, Herr DR. Activation of sphingosine 1-phosphate receptor 2 attenuates chemotherapy-induced neuropathy. J Biol Chem. 2020 Jan 24;295(4):1143-1152. doi: 10.1074/jbc.RA119.011699. Epub 2019 Dec 27. PMID: 31882542; PMCID: PMC6983853.
15.
Wong LW, Tann JY, Ibanez CF, Sajikumar S. The p75 Neurotrophin Receptor Is an Essential Mediator of Impairments in Hippocampal-Dependent Associative Plasticity and Memory Induced by Sleep Deprivation. J Neurosci. 2019 Jul 10;39(28):5452-5465. doi: 10.1523/JNEUROSCI.2876-18.2019. Epub 2019 May 13. PMID: 31085607; PMCID: PMC6616296.