This Executive Certificate was developed in reaction to the growing complexity and impact of the development of novel biotechnologies. Such development requires attention to best practice and ethical conduct of research, in some cases balancing the protection of participants with the social value of knowledge produced. Standards of research conduct have been developed over the past few decades to systematically promote ethical study design and conduct, and responsible biotechnological innovation requires familiarity with these standards and their justifications. Beyond the standards of research ethics, three topical areas are of substantial interest as well as concern in the development of novel biotechnologies. First, biotechnological development is increasingly reliant on big data and AI analytics, which can be harnessed to great potential public and private benefit but raises concerns about privacy and accountable oversight. Second, the precision medicine movement aims to transform healthcare through better tailoring treatments to individual patient profiles, along the way raising questions about the ethical, legal and social implications (ELSI) of its reliance on genomics. Third, the COVID-19 pandemic led to an unprecedented burst of biotechnological research, international collaboration and rapid deployment of novel interventions around the world. We are now seeing the fruits of that effort, but along the way careful balance is needed between the rush to provide effective interventions and the need to ensure the process is reliable, trustworthy and sustainable. This course will not just raise these ethical issues, but will provide students with the practical tools needed to deliberate over and resolve them in a variety of contexts.