This specialised course is tailored for middle to senior-level healthcare professionals who aim to lead change in their settings. With a focus on developing clinical practice guidelines and public policies, the course offers a rigorous, evidence-based approach to healthcare decision-making at various levels. Participants will journey from understanding the fundamentals of healthcare leadership and the role of evidence, to mastering economic evaluation and implementation strategies. The course concludes with practical application, guiding students in translating evidence into clinical guidelines and public policy recommendations. 1. Understand the foundational role of leadership in healthcare change and its relationship to evidence-based practice.2. Master the techniques to identify, assess, and synthesise high-quality evidence for healthcare decision-making.3. Acquire skills in applying health economics for robust economic evaluation in clinical guideline development.4. Gain a nuanced understanding of the global context affecting health policy, including technological advancements and socioeconomic factors.5. Develop skills in designing research methodologies tailored to specific healthcare questions.6. Learn how to adapt international evidence and global policies for local contexts, considering cultural, fiscal, social, technical and ethical aspects.7. Translate evidence into clinical practice guidelines and public policy recommendations.8. Navigate challenges and formulate solutions when faced with limited, conflicting, poor-quality or no evidence.